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Chemical tweaks to a toad hallucinogen turns it into a potential drug

Fri, 05/10/2024 - 11:05

Enlarge / The Colorado River toad, also known as the Sonoran Desert Toad. (credit: Mark Newman)

It is becoming increasingly accepted that classic psychedelics like LSD, psilocybin, ayahuasca, and mescaline can act as antidepressants and anti-anxiety treatments in addition to causing hallucinations. They act by binding to a serotonin receptor. But there are 14 known types of serotonin receptors, and most of the research into these compounds has focused on only one of them—the one these molecules like, called 5-HT2A. (5-HT, short for 5-hydroxytryptamine, is the chemical name for serotonin.)

The Colorado River toad (Incilius alvarius), also known as the Sonoran Desert toad, secretes a psychedelic compound that likes to bind to a different serotonin receptor subtype called 5-HT1A. And that difference may be the key to developing an entirely distinct class of antidepressants.

Uncovering novel biology

Like other psychedelics, the one the toad produces decreases depression and anxiety and induces meaningful and spiritually significant experiences. It has been used clinically to treat vets with post-traumatic stress disorder and is being developed as a treatment for other neurological disorders and drug abuse. 5-HT1A is a validated therapeutic target, as approved drugs, including the antidepressant Viibryd and the anti-anxiety med Buspar, bind to it. But little is known about how psychedelics engage with this receptor and which effects it mediates, so Daniel Wacker’s lab decided to look into it.

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Automakers hedge their bets with plug-in hybrids as EV sales slow

Fri, 05/10/2024 - 10:57

Enlarge (credit: Honda)

Global carmakers are stepping up their investment in hybrid technologies as consumers’ growing wariness over fully electric vehicles forces the industry to rapidly shift gear, according to top executives.

A combination of still high interest rates and concern over inadequate charging infrastructure has chilled buyers’ enthusiasm for fully electric cars, prompting a rebound in sales of hybrid vehicles that most of the industry had long regarded as nothing more than a stop-gap.

Tapping the resurgent demand for hybrids was a priority, executives from General Motors, Nissan, Hyundai, Volkswagen and Ford told the Financial Times’ Future of the Car Summit this week.

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US Cellular is for sale, reportedly could be “carved up” by major carriers

Fri, 05/10/2024 - 10:46

Enlarge (credit: Getty Images | SOPA Images )

T-Mobile is reportedly close to buying a portion of the regional carrier US Cellular, while Verizon has also held talks about buying some of US Cellular's assets. "T-Mobile is closing in on a deal to buy a chunk of the regional carrier for more than $2 billion, taking over some operations and wireless spectrum licenses, according to people familiar with the matter," The Wall Street Journal reported yesterday.

When contacted by Ars today, T-Mobile said it doesn't "comment on rumors and speculation." We contacted US Cellular and will update this article if we get a response.

T-Mobile is one of just three major nationwide carriers. There were four until T-Mobile bought Sprint in 2020. T-Mobile also completed an acquisition of prepaid carrier Mint Mobile less than two weeks ago.

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Apple apologizes for ad that crushes the sum total of human artistic endeavor

Fri, 05/10/2024 - 10:31

Enlarge / One of many human-created objects destroyed in Apple's "Crush!" ad for the iPad Pro. (credit: Apple)

Earlier this week, Apple took the wraps off of a thoroughly leaked iPad Pro refresh with a 1 minute and 8 second ad spot wherein a gigantic hydraulic press comprehensively smushes a trumpet, an arcade cabinet, a record player, paint cans, a piano, a TV, sculptures, a bunch of emoji, and plenty of other tools that one might loosely categorize as "artistic implements."

At the end of the ad, the press lifts away to reveal a somewhat thinner, somewhat faster version of Apple's iPad Pro. The message of the ad, titled "Crush!" and still available via Apple's YouTube channel and CEO Tim Cook's Twitter account, is obvious: look at all of the things we've squeezed into this tablet!

"Just imagine all the things it'll be used to create," wrote Cook.

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Phantom braking lands troubled EV-maker Fisker in feds’ crosshairs

Fri, 05/10/2024 - 09:18

Enlarge (credit: Graham Hughes/Bloomberg via Getty Images)

The federal government is looking at a phantom braking problem that appears to be affecting the Fisker Ocean electric crossover. Earlier this week, the National Highway Traffic Safety Administration's Office of Defects Investigation opened a safety probe into the electric vehicle—its fourth so far. Open investigations are also examining whether the doors can fail to open, in addition to problems with shifting into or out of park and issues with partial braking loss over low-grip surfaces.

The newest preliminary investigation was opened by NHTSA's ODI after the regulator received eight complaints of alleged inappropriate automatic emergency braking. AEB is one of the more effective new active driver safety systems. NHTSA added it to its list of recommended safety features almost a decade ago, and last month, it published industry standards that will make the feature mandatory on all new cars and trucks, although not until September 2029.

But not every AEB implementation is equal. Both Tesla's and Honda's systems have suffered from too many false positives, also known as phantom braking, triggering the feature inappropriately, sometimes resulting in that car being crashed into from behind.

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The wasps that tamed viruses

Fri, 05/10/2024 - 08:52

Enlarge / Xorides praecatorius is a parasitoid wasp. (credit: TorriPhoto via Getty)

If you puncture the ovary of a wasp called Microplitis demolitor, viruses squirt out in vast quantities, shimmering like iridescent blue toothpaste. “It’s very beautiful, and just amazing that there’s so much virus made in there,” says Gaelen Burke, an entomologist at the University of Georgia.

M. demolitor  is a parasite that lays its eggs in caterpillars, and the particles in its ovaries are “domesticated” viruses that have been tuned to persist harmlessly in wasps and serve their purposes. The virus particles are injected into the caterpillar through the wasp’s stinger, along with the wasp’s own eggs. The viruses then dump their contents into the caterpillar’s cells, delivering genes that are unlike those in a normal virus. Those genes suppress the caterpillar’s immune system and control its development, turning it into a harmless nursery for the wasp’s young.

The insect world is full of species of parasitic wasps that spend their infancy eating other insects alive. And for reasons that scientists don’t fully understand, they have repeatedly adopted and tamed wild, disease-causing viruses and turned them into biological weapons. Half a dozen examples already are described, and new research hints at many more.

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Analyst on Starlink’s rapid rise: “Nothing short of mind-blowing”

Fri, 05/10/2024 - 08:45

Enlarge / 60 Starlink satellites stacked for launch at SpaceX facility in Cape Canaveral, Florida in 2019. (credit: SpaceX)

According to the research firm Quilty Space, SpaceX's Starlink satellite Internet business is now profitable.

During a webinar on Thursday, analysts from the firm outlined the reasons why they think SpaceX has been able to achieve a positive cash flow in its space Internet business just five years after the first batch of 60 satellites were launched.

The co-founder of the firm, Chris Quilty, said the rapidity of Starlink's rise surprised a lot of people, including himself. "A lot of industry veterans kind of scoffed at the idea," he said. "We'd seen this before."

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Outdoing the dinosaurs: What we can do if we spot a threatening asteroid

Fri, 05/10/2024 - 06:00

Enlarge / We'd like to avoid this. (credit: Science Photo Library/Andrzej Wojcicki/Getty Images)

In 2005, the United States Congress laid out a clear mandate: To protect our civilization and perhaps our very species, by 2020, the nation should be able to detect, track, catalog, and characterize no less than 90 percent of all near-Earth objects at least 140 meters across.

As of today, four years after that deadline, we have identified less than half and characterized only a small percentage of those possible threats. Even if we did have a full census of all threatening space rocks, we do not have the capabilities to rapidly respond to an Earth-intersecting asteroid (despite the success of NASA’s Double-Asteroid Redirection Test (DART) mission).

Some day in the finite future, an object will pose a threat to us—it’s an inevitability of life in our Solar System. The good news is that it’s not too late to do something about it. But it will take some work.

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Rocket Report: German launch from Australia; Neutron delayed until 2025

Fri, 05/10/2024 - 06:00

Enlarge / HyImpulse's single-stage rocket, SR75, lifts off from Australia. (credit: HyImpulse)

Welcome to Edition 6.43 of the Rocket Report! This week saw the debut of two new rockets, a suborbital lifter from a German startup, and a new variant of the Long March 6 from China's state-owned launch provider. We also got within two hours of the debut of a crewed launch of Boeing's Starliner vehicle, but a rocket issue forced a 10-day delay. Soon, hopefully.

As always, we welcome reader submissions, and if you don't want to miss an issue, please subscribe using the box below (the form will not appear on AMP-enabled versions of the site). Each report will include information on small-, medium-, and heavy-lift rockets as well as a quick look ahead at the next three launches on the calendar.

Orbital launch tally running ahead of 2023. There were 63 orbital launch attempts worldwide in the first quarter of 2024, which is 10 more than the same time last year, Payload reports. SpaceX accounted for 32 of the 34 US orbital launch attempts in Q1. One ULA Vulcan launch and one Rocket Lab Electron launch out of Wallops rounded out the remaining total. (Rocket Lab flights out of New Zealand are not counted in US launch totals.)

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First Dream Chaser spaceplane needs more work when it gets to launch site

Thu, 05/09/2024 - 19:18

Enlarge / Sierra Space's Dream Chaser spaceplane inside a NASA test chamber in Ohio. (credit: Sierra Space)

There is still some work to do to prepare Sierra Space's Dream Chaser spaceplane for its first mission, but the company says the winged resupply craft for the International Space Station will soon ship to its launch site in Florida.

The Dream Chaser will take off on top of a United Launch Alliance Vulcan rocket to head for the space station. A spokesperson for Sierra Space told Ars the spaceplane's launch is scheduled for the third or fourth quarter of this year.

But Sierra Space will transport the Dream Chaser to NASA's Kennedy Space Center in Florida with a to-do list. There are two more significant tests the spacecraft must complete at the launch site. Technicians must also finish work on Dream Chaser's heat shield before it is ready to go on top of its Vulcan launcher. It's unclear how long these activities will take to complete.

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Fedora Asahi Remix 40 is another big step forward for Linux on Apple Silicon Macs

Thu, 05/09/2024 - 17:49

Enlarge / RIP, Neofetch. (credit: Kevin Purdy)

Asahi Linux, the project that aims to bring desktop Linux to Apple hardware with Apple silicon—the M series of chips—is out with Fedora Asahi Remix 40. More hardware features of Apple devices are supported, the Fedora Linux 40-based distro ships with KDE's new Plasma 6 desktop, and untold numbers of bugs are squashed, to be replaced with reams more.

Fedora Asahi Remix is a "fully integrated distro," according to the Asahi team, and you can "expect a solid and high-quality experience without any unwanted surprises." It supports all the M1 and M2 devices in the MacBook, Mac Mini, Mac Studio, and iMac lines. It's OpenGL 4.6 and OpenGL ES 3.2 certified, and comes with "the best Linux laptop audio you've ever heard."

So, should you install it on your Mac? Keep scrolling down Asahi's release page and check the "Device support" section. Still missing from most M-series Apple devices are support for Thunderbolt and USB4, built-in microphones, and Touch ID, as well as USB-C display support. Speakers are not supported on the iMac. And HDMI audio is in rough shape, being able to "break audio on the system completely."

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Stack Overflow users sabotage their posts after OpenAI deal

Thu, 05/09/2024 - 16:20

Enlarge (credit: Getty Images)

On Monday, Stack Overflow and OpenAI announced a new API partnership that will integrate Stack Overflow's technical content with OpenAI's ChatGPT AI assistant. However, the deal has sparked controversy among Stack Overflow's user community, with many expressing anger and protest over the use of their contributed content to support and train AI models.

"I hate this. I'm just going to delete/deface my answers one by one," wrote one user on sister site Stack Exchange. "I don't care if this is against your silly policies, because as this announcement shows, your policies can change at a whim without prior consultation of your stakeholders. You don't care about your users, I don't care about you."

Stack Overflow is a popular question-and-answer site for software developers that allows users to ask and answer technical questions related to coding. The site has a large community of developers who contribute knowledge and expertise to help others solve programming problems. Over the past decade, Stack Overflow has become a heavily utilized resource for many developers seeking solutions to common coding challenges.

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The Volvo VNL, a heavy truck purpose-designed for North American roads

Thu, 05/09/2024 - 15:45

Enlarge / America sends five times more freight by truck than rail, so it's important to start making those trucks more fuel efficient and safer. (credit: Volvo Trucks North America)

A while ago we checked out Super Truck II, a Department of Energy program that has been challenging the makers of Class 8 heavy trucks—the ones that haul up to 80,000 lbs (36.3 tonnes) of freight. Truck companies like Daimler Trucks North America and Volvo Trucks North America were challenged to build a big rig that used 50 percent less fuel than the machines on the road in 2017, and they stepped up.

It'll be a while before all of the efficiency improvements make their way onto production trucks, as that program has only just come to a close. But the truck makers are already starting to apply some of the lessons to production vehicles. Like Volvo's new VNL, a Class 8 long-haul truck that's been purpose-built just for our market.

"It's replacing the previous generation that had been around for several decades," explained Keith Brandis, VP of systems and solutions at VTNA. That was based on a global cab concept and design, where this was a completely new clean sheet for North America."

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Solid-state polymer heat pump gets rid of the heat itself

Thu, 05/09/2024 - 15:35

Enlarge (credit: Jorg Greuel)

Heat pumps are the most energy-efficient way of controlling indoor temperature. By moving heat between locations, they avoid the inefficiencies of generating heat in the first place. But that doesn't mean they can't be made more efficient.

Most current heat pumps rely on materials that exhibit large changes in temperature in response to changing pressures, but the energy required to pressurize them gets lost when they're cycled back to a low-pressure state, absorbing heat from their surroundings. That has gotten people interested in electrocaloric devices, where changes in temperature are driven by storing charges in a material. Since it essentially acts as a big capacitor, much of the electrical energy involved can be pulled back out as the system cycles.

But capacitors aren't especially mobile, so electrocaloric systems tended to use fluids to move heat into and out of the capacitor as it cycles. Now, however, researchers have developed an electrocaloric system that moves itself between hot and cold environments, radically simplifying the system and eliminating some of the energy required for it to operate. They even demonstrate it effectively cooling a computer chip.

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Leaked FBI email stresses need for warrantless surveillance of Americans

Thu, 05/09/2024 - 14:35

Enlarge (credit: Getty Images | Yuichiro Chino)

A Federal Bureau of Investigation official recently urged employees to "look for ways" to conduct warrantless surveillance on US residents, an internal email obtained by Wired shows. FBI Deputy Director Paul Abbate's email was reportedly sent on April 20, the same day President Biden signed a bill that was criticized as a major expansion of warrantless surveillance under Section 702 of the Foreign Intelligence Surveillance Act (FISA).

Abbate's email seems to argue that FBI employees should make frequent use of warrantless surveillance on US people in order to justify the continued existence of the program. "To continue to demonstrate why tools like this are essential to our mission, we need to use them, while also holding ourselves accountable for doing so properly and in compliance with legal requirements," Abbate wrote, according to Wired.

Abbate oversees all FBI domestic and international investigative and intelligence activities. His email made reference to a new requirement that FBI personnel obtain prior approval from an FBI supervisor or attorney before making queries about US people.

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Dell warns of “incident” that may have leaked customers’ personal info

Thu, 05/09/2024 - 13:40

Enlarge (credit: Getty)

For years, Dell customers have been on the receiving end of scam calls from people claiming to be part of the computer maker’s support team. The scammers call from a valid Dell phone number, know the customer's name and address, and use information that should be known only to Dell and the customer, including the service tag number, computer model, and serial number associated with a past purchase. Then the callers attempt to scam the customer into making a payment, installing questionable software, or taking some other potentially harmful action.

Recently, according to numerous social media posts such as this one, Dell notified an unspecified number of customers that names, physical addresses, and hardware and order information associated with previous purchases was somehow connected to an “incident involving a Dell portal, which contains a database with limited types of customer information.” The vague wording, which Dell is declining to elaborate on, appears to confirm an April 29 post by Daily Dark Web reporting the offer to sell purported personal information of 49 million people who bought Dell gear from 2017 to 2024.

Ad posted to Breach Forums, as reported by Daily Dark Web. (credit: Daily Dark Web)

The customer information affected is identical in both the Dell notification and the for-sale ad, which was posted to, and later removed from, Breach Forums, an online bazaar for people looking to buy or sell stolen data. The customer information stolen, according to both Dell and the ad, included:

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Discover why the world went quiet in new A Quiet Place: Day One trailer

Thu, 05/09/2024 - 13:28

Lupita Nyong'o and Joseph Quinn must escape a Manhattan overrun by aliens in A Quiet Place: Day One.

Invading aliens transform a bustling New York City into a silent wasteland in the latest trailer for A Quiet Place: Day One, a prequel to the first two films in the hugely successful horror franchise.

(Mild spoilers for A Quiet Place and A Quiet Place: Part II below.)

As reported previously, the original film began in medias res over a month after an alien invasion set in early 2020. Sightless extraterrestrial creatures wiped out most of the humans and animals on Earth. They hunt by sound thanks to their hypersensitive hearing and are difficult to kill because they sport tough armored skin. The film centered on the Abbott family, struggling to survive a few months after the initial invasion. Dad Lee (John Krasinski) was an engineer focused on keeping his family alive each day. Wife Evelyn (Emily Blunt) was a doctor, pregnant with their fourth child.

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The 2024 Moto G Stylus is a $400 mid-ranger with vegan leather

Thu, 05/09/2024 - 13:18

Motorola's latest phone is the 2024 Moto G Stylus 5G. For fans of pen input there isn't much out there other than this and the Galaxy S Ultra line, but for $400 you can get a phone with a stowable stylus.

The design is just a bit interesting thanks to the "vegan leather" (that's a type of plastic) back, which gives the phone some personality. You get flat aluminum sides, a flat screen, and a hole-punch camera. Android does not have a lot of built-in stylus features, so you'll mostly be relying on whatever Motorola has cooked up; the website only shows a "Moto Note" app and the ability to send your drawings over instant messaging, plus there's whatever you can find on the Play Store.

This is a mid-range phone, so for the SoC, we have a Qualcomm Snapdragon 6 Gen 1. That's four Arm Cortex A78 cores and four Cortex A55 cores, built with a quite modern 4 nm process. There's a 6.7-inch, 120 Hz, 2400×1080 OLED display, 8GB of RAM, 256GB of storage, and a 5000 mAh battery with 30 W wired charging and 15 W wireless charging. Pictures will come from a 50 MP main camera, 13 MP wide-angle, or a front 32 MP camera. There's a MicroSD slot, headphone jack, in-screen fingerprint reader, stowable stylus (of course), and NFC. Wi-Fi only goes up to 802.11ac. That's "Wi-Fi 5" and is pretty old, but it will get the job done, I guess. The "IP52" dust- and water-resistant rating is also not great, promising only protection from some water drops at certain angles.

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Apple’s plastic-free packaging means pack-in logo stickers are going away

Thu, 05/09/2024 - 13:10

Enlarge / Many different Apple stickers from many different products and eras. (credit: Andrew Cunningham)

As a noted sticker enthusiast, I’m always on the lookout for news at the intersection of stickers and technology. Which is why this report from 9to5Mac caught my eye: Apple is apparently starting to wind down its decades-long practice of including Apple logo stickers in the box with all of its products.

If you buy a new iPad Air or iPad Pro, you’ll be able to get some stickers if you ask the people at the Apple Store to include them (stores will get a “limited quantity” of stickers they can distribute on request). But the little sticker insert that has come with Macs, iPods, iPhones, iPads, and other devices and accessories for as long as I can remember will stop being one of the default pack-ins.

Apple is apparently cutting down on its sticker distribution to help meet its environmental goals. The stickers are some of the last bits of plastic included in most modern Apple packaging; in recent years, even the plastic backing layer for the stickers has been replaced with wax paper instead. This happened around the same time that the inner layer of packaging wrapped around new Apple devices also shifted from plastic to paper and when plastic-sealed boxes gave way to tear-away paper adhesive strips.

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Vermont close to becoming first state to charge Big Oil for climate damage

Thu, 05/09/2024 - 12:58

Enlarge / Ripton, VT - July 16, 2023: Ethan Poploski stood in front of his family's home, which had been destroyed by a landslide overnight. (credit: Boston Globe / Contributor | Boston Globe)

Vermont may soon become the first state to force fossil fuel companies to pay their fair share to cover recovery efforts from climate change damages. This week, the state's potentially groundbreaking law passed a preliminary vote in the Senate, where a final vote is expected soon that would likely send the law to the governor's desk. And there's reportedly broad enough support to override any attempt to veto the law.

By passing a law that mimics the Environmental Protection Agency’s Superfund program—which "forces the parties responsible for the contamination" of lands "to either perform cleanups or reimburse the government for EPA-led cleanup work"—Vermont hopes to create a Climate Superfund Cost Recovery Program.

If enacted, the law could end up costing fossil fuel companies billions for climate damages in Vermont alone and serve as a model for other states similarly seeking to combat their worst impacts.

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